Inclusion criteria

Exclusion criteria

-       Post-AMI patients with LDL > 100 mg/dL.

-       Patients with LDL cholesterol >130 mg/dL after 3 months of non-pharmacological treatment and at least one of the following conditions: HDI proven by ET or MS, previous AMI , previous myocardial revascularization or coronary angiography with greater than 30% obstruction lesions; atherosclerotic disease in other arterial beds: peripheral vascular disease with intermittent claudication or obstruction greater than 50% doppler, abdominal aortic aneurysm and/or symptomatic carotid disease; DM; genetic syndromes: familiar hypercholesterolemia and familiar combined hyperlipidemia; absolute Framingham score high (≥9 points for men and ≥15 points for women).

-       Patients with LDL > 160 mg/dL cholesterol after 6 months of non-pharmacological treatment and at least one of the following conditions: absolute Framingham score high (≥6 points for men and for women ≥10 points); at least 2 of the following factors: age >55 years, Hypertension, HDL < 40 mg/dL, smoking (in the presence of mental retardation or severe psychiatric disorder only).

-       Pregnant or situations where pregnancy can not be avoided;

-       Lactation;

-       Active or chronic liver disease;

-       Persistent elevation of transaminases;

-       A history of hypersensitivity to statins and fibrates;

-       Myositis or polymyositis;

-       Proven inability to adherence to exercise programs, except for cases of physical or mental disability;

-       Neoplasms or terminal illness with less than two years estimated survival;

-       Untreated hypothyroidism;

-       Alcohol use or abuse of drugs present;

-       Continuity of smoking